the association of subclinical hypothyroidism and pattern of circulating endothelial-derived microparticles among chronic heart failure patients
نویسندگان
چکیده
conclusions we believe that the sh state in chf patients may be associated with the impaired pattern of circulating emps, with the predominantly increased number of apoptotic-derived microparticles. background subclinical hypothyroidism (sh) is diagnosed biochemically by the presence of normal serum free thyroxine concentration, in conjunction with an elevated serum thyroid-stimulating hormone level. recent studies have demonstrated the frequent association between sh and cardiovascular diseases and risk factors. objectives to evaluate the impact of sh on patterns of circulating endothelial-derived microparticles, (emps) among chronic heart failure (chf) patients patients and methods this is a retrospective study involving a cohort of 388 patients with chf. fifty-three chf subjects had sh and 335 patients were free from thyroid dysfunction. circulating levels of n-terminal-pro brain natriuretic peptide (nt-probnp), high-sensitivity c-reactive protein (hs-crp), thyroid-stimulating hormone (tsh), total and free thyroxine (t4), and triiodothyronine (t3), and endothelial apoptotic microparticles (emps), were measured at baseline. sh was defined, according to contemporary clinical guidelines, as a biochemical state associated with an elevated serum tsh level of greater 10 μu/l and normal basal free t3 and t4 concentrations. results circulating cd31+/annexin v+ emps were higher in patients with sh compared to those without sh. in contrast, activated cd62e+ emp numbers were not significantly different between both patient cohorts. using uni (bi) variate and multivariate age- and gender-adjusted regression analysis, we found several predictors that affected the increase of the cd31+/annexin v+ to cd62e+ ratio in the patient study population. the independent impact of tsh per 6.5 μu/l (odds ratio [or] = 1.23, p = 0.001), sh (or = 1.22, p = 0.001), nt-probnp (or = 1.19, p = 0.001), nyha class (or = 1.09, p = 0.001), hs-crp per 4.50 mg/l (or = 1.05, p = 0.001), dyslipidemia (or = 1.06, p = 0.001), serum uric acid per 9.5 mmol/l (or = 1.04, p = 0.022) on the increase in the cd31+/annexin v+ to cd62e+ ratio, was determined.
منابع مشابه
The Association of Subclinical Hypothyroidism and Pattern of Circulating Endothelial-Derived Microparticles Among Chronic Heart Failure Patients
BACKGROUND Subclinical hypothyroidism (SH) is diagnosed biochemically by the presence of normal serum free thyroxine concentration, in conjunction with an elevated serum thyroid-stimulating hormone level. Recent studies have demonstrated the frequent association between SH and cardiovascular diseases and risk factors. OBJECTIVES To evaluate the impact of SH on patterns of circulating endothel...
متن کاملImpaired Pattern of Endothelial Derived Microparticles in Heart Failure Patients
Chronic heart failure (CHF) remains a leading cause of cardiovascular morbidity and mortality worldwide that is characterized pandemic features. Metabolic diseases, neurohumoral state, and systemic inflammatory response are considered the origin of microvascular endothelial cell inflammation that leads to development of CHF and supporting cardiac remodelling and vascular dysfunction. Endothelia...
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•Circulating microparticles may interplay in vascular remodeling and tissue reparation.•Heart failure associates with elevated apoptotic and decreased activated endothelial cell-derived microparticles.•Imbalance between numbers of apoptotic and activated endothelial cell microparticles reflects impaired immune phenotype.•Impaired immune phenotype of microparticles might discuss a surrogate mark...
متن کاملThe predictive role of circulating microparticles in patients with chronic heart failure☆
AIM The study aim was to evaluate whether circulating microparticles with apoptotic or non-apoptotic phenotypes are useful for risk assessment of 3-year cumulative fatal and non-fatal cardiovascular events in CHF patients. METHODS The incidence of fatal and non-fatal cardiovascular events, as well as the frequency of occurrence of death from any cause in a cohort of 388 patients with CHF duri...
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متن کامل
[Improvement in functional capacity after levothyroxine treatment in patients with chronic heart failure and subclinical hypothyroidism].
AIM To assess whether levothyroxine treatment improves functional capacity in patients with chronic heart failure (New York Heart Association class i-iii) and subclinical hypothyroidism. METHODS One hundred and sixty-three outpatients with stable chronic heart failure followed up for at least 6 months were enrolled. A physical examination was performed, and laboratory tests including thyroid ...
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عنوان ژورنال:
research in cardiovascular medicineجلد ۴، شماره ۴، صفحات ۰-۰
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